Efficacy of Two Prophylactic Schedules (Prulifloxacin Versus Phosphomycin)
Status:
Unknown status
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Epidemiological studies showed that 20-30% of patients with uncomplicated urinary tract
infections risked recurrent infection. Urinary tract infection causes marked discomfort for
the patient, has a negative impact upon quality of life, and is associated with high social
and health costs in terms of specialist appointments, laboratory and instrumental tests and
prescriptions . Although diverse cycles of antibiotic therapy and prophylaxis have been
proposed, doubts persist about the most efficacious pharmacological agents, duration of
prophylaxis , the incidence of adverse effects and relapse when antibiotic therapy is
suspended.
Aims of the study:
1. To compare the efficacy of two prophylactic schedules (Prulifloxacin vs Phosphomycin):
- in reducing the number of urinary tract infection episodes during prophylaxis
- in reducing the number of urinary tract infection episodes after prophylaxis
- in improving the patient's quality of life .
2. To assess :
- Tolerability of antibiotic prophylaxis
- The incidence of resistance to antibiotic therapy