Efficacy of Topical Capsaicin Cream for Stable Angina

• Status: Terminated
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the hypothesis that application of topical capsaicin in patients with stable angina will result in improved exercise tolerance and reduced cardiac ischemia.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Neal Weintraub
• Collaborator: University of Cincinnati
• Treatments: Capsaicin

Criteria

Inclusion Criteria:

• > or = 3 month history of chronic, stable, angina triggered by physical effort or mental/emotional stress

• documented stress-induced ST depression, reversible perfusion imaging, or wall motion abnormality or CAD >50%

• Canadian Cardiovascular (CV) Class I-III

• Receiving medical therapy for > or = 2 months

• Ability to perform Bruce Protocol treadmill test

• non-pregnant female

Exclusion Criteria:

• unstable angina

• revasc within 2 months

• Myocardial infarction (MI) within 2 months

• congestive heart failure (CHF) hospitalization within 2 months

• New York Heart Association (NYHA) class III or IV

• left ventricular ejection fraction (LVEF) < 25%

• abnormal ECG; Acute changes on ECG

• Currently receiving treatment with investigational drugs/devices

• Uncontrolled hypertension

• contraindication to exercise stress testing

• allergy to red peppers or capsaicin

• skin deformity, scar, or rash at application site

• abdominal surgery within 3 months