Efficacy of Ticagrelor Plus Aspirin in Minor Non-cardioembolic Ischemic Stroke

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, controlled, active comparator arm, outcome assessor blind, parallel group design on 90 patient with diagnosis of ischemic stroke admitted in Bou-Ali Sina Hospital, Sari,Iran.The aim of study is assess the efficacy of ticagrelor plus aspirin in reduce of minor non-cardioembolic ischemic stroke or high risk TIA recurrence during first 3 months.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mazandaran University of Medical Sciences
• Treatments: Clopidogrel; Ticagrelor

Criteria

Inclusion Criteria:

• signing inform consent,

• recent ischemic stroke within 24 h,

• diagnosed by brain CT or MRI mild stroke (non lacunar) with NIHSS =<8,

• high risk TIA with ABCD >4,

• no cardioembolic source such as low E/F, MS, AF ,...

• no specific etiology such as dissection, vasculitis, ...

• no carotid stenosis > 50 % in side of involvement

Exclusion Criteria:

• history of hypersensitivity to consumptive drug

• any indication for anticoagulant therapy

• acute phase treatment with intravenous thrombolysis or thrombectomy

• any contraindication for consumptive drug

• history of intracranial hemorrhage

• history of GI bleeding during past 6 m

• candidate for endarterectomy

• history of coagulopathy

• active hemorrhagic diatesis during randomization