Efficacy of Sugammadex in Magnesium Pretreated Patients
Status:
Completed
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
Sugammadex is a new reversal agent for neuromuscular blockers (curare). It encapsulates the
curare molecule and terminates immediately its action. The recommended dose is 2 mg/kg for a
slight neuromuscular block and 4 mg/kg for a profound neuromuscular block. Magnesium sulphate
is frequently used in perioperative medicine and it is known to reinforce the neuromuscular
block induced for instance by rocuronium. The researchers want to investigate, whether higher
doses of sugammadex must be given to antagonize the neuromuscular block induced by rocuronium
in patients who received magnesium sulphate.