Efficacy of Steroid Versus Steroid Plus Cyclophosphamide for Severe Henoch-Schoenlein Purpura
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Henoch-Schonlein purpura is a leucocytoclastic systemic vasculitis involving small vessels
with the deposition of immune complexes containing IgA. It is characterized by the
association of skin, joint and gastrointestinal manifestations. Even though the evolution is
usually simple, some patients, especially adults, may have severe visceral involvement
including heart, lung, brain and renal disease. The best treatment is currently unknown. This
study will test the safety and efficacy of steroids associated or not with cyclosphosphamide
to treat the acute lesions and to prevent the development of chronic lesions.