To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy
of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B:
body mass , O: bronchial obstruction, D: dyspnea and, E: exercise tolerance) index; (4) Uric
acid; and, (5)vascular growth factors. Design: a 12 weeks randomized (1:1), double-blind,
placebo control study. Population: 18 males with stable COPD between 40-80 years of age,
exsmokers, with Forced expiratory volume in one second (FEV1) between 30 and 80% predicted
post-bronchodilation.
Phase:
Phase 3
Details
Lead Sponsor:
Hospital Universitari Son Dureta
Collaborators:
Cimera Fundació d'investigació Sanitària de les Illes Balears