Overview

Efficacy of Sildenafil in the Improvement of Cognition and Quality of Life in Patients With Cirrhosis of Liver. A Proof of Concept Study.

Status:
Unknown status

Trial end date:
2014-01-01

Target enrollment:

Participant gender:

Summary

The study is being conducted to evaluate the efficacy of Sildenafil (a 5-phosphodiesterase inhibitor) as a means to improve the cognitive impairment encountered in patients of minimal hepatic encephalopathy (MHE) as proposed in different studies. This study would also assess the role of improvement of cognition as a means of improvement in quality of life.The patients will receive Sildenafil or no treatment for 4 weeks. This study may prove and provide important therapeutic strategy for cognition impairment in patients with MHE.

Phase:

Phase 1/Phase 2

Details

Lead Sponsor:

Postgraduate Institute of Medical Education and Research

Treatments:

Phosphodiesterase 5 Inhibitors
Sildenafil Citrate