Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance
Status:
Terminated
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
The investigators will study whether, in young children with acute otitis media (AOM),
shortening length of antibiotic treatment as a strategy for reducing antimicrobial resistance
provides satisfactory clinical outcome. This is a Phase 2b multicenter, randomized,
double-blind, placebo-controlled clinical trial in 600 children aged 6 through 23 months
comparing the efficacy of consistent reduced-duration antimicrobial treatment (5 days) with
that of consistent standard-duration treatment (10 days) for each episode of AOM developing
during a single respiratory season (October 1 through May 31).
Phase:
Phase 2
Details
Lead Sponsor:
Alejandro Hoberman
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)