Efficacy of Selegiline in Negative Symptoms of Schizophrenia
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
Antipsychotic drugs are effective in treating the positive symptoms of schizophrenia; however
their efficacy in treating negative symptoms is limited. This study wants to evaluate
efficacy of selegiline augmentation of antipsychotic medication to treat negative symptoms in
inpatients with chronic schizophrenia. With randomized clinical trial two groups of patients
will select to receive selegiline or placebo.
Primary end point is decreasing in negative symptoms in case group. Inclusion criteria : 1-
Patients with moderate to severe negative symptoms 2- Patients with at least one year
antipsychotic drug therapy, at the current dose >= 1 month. 3- No other psychotropic drugs
during past month. Exclusion criteria: 1- Severe major depressive disorder, substance abuse,
severe positive symptoms of schizophrenia, Treatment of MDD with antidepressant drugs during
past month.