Patients with depression (target number - 60) receive resveratrol 500 mg or placebo (1:1)
each morning daily for 1 month with primary outcome measures of the score change on
depression rating scale HDRS-17 and change in SIRT1 activity in the blood measured 4 times
over the study period (before, in the middle, after the intervention, and in 2 week follow
up).