Efficacy of Rectal Indomethacin in Prevention of Post-operative Pancreatitis After Pancreaticoduodenectomy
Status:
Recruiting
Trial end date:
2022-03-31
Target enrollment:
Participant gender:
Summary
Pancreatico-duodenectomy is one of the commonly performed procedure for periampullary/distal
cholangio/head of pancreas carcinoma. Post operative pancreatitis is an emerging concept,
recently being studied as one of the most important contributing factor of Post-operative
pancreatic fistula, which is one of the major complication of pancreatoduodenectomy. Rectal
indomethacin, a type of non-steroidal anti-inflammatory drug, when given in a single dose has
been shown to prevent pancreatitis in patients undergoing ERCP. In this study, we will be
administering rectal indomethacin at the time of induction of anesthesia to the experimental
arm of the study and compare the results in terms of incidence of post-operative pancreatitis
in the two groups.