Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns
Status:
Unknown status
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types
including fibroblasts, smooth muscle and connective tissue. Recombinant human platelet
derived growth factor (R-Pdf/Gbb) has biologic activity similar to endogenous platelet
derived growth factor (PDGF). Biologic activity of PDGF includes encouraging chemotaxis and
proliferation of cells responsible for wound repair and it augments production of granulation
tissue.
The growth factor rhPDGF is found effective in patients having diabetic foot ulcer grade III
and IV. The nature of wounds in the third degree burns is similar so far as healing process
is concerned.
The purpose of this study is to test the hypotheses that the application of R-Pdf/Gbb 0.01%
gel on the third degree thermal and electrical burns will heal these wounds within 3 months
and there will be improvement in general condition of the patients without any complications.