Efficacy of Purslane in Treatment of Oral Lichen Planus
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Oral lichen planus (OLP) is a chronic inflammatory disease whose prevalence in the general
population is 0.5 -2.2%.Oral lesions in OLP are chronic, rarely undergo spontaneous
remission. Patients with OLP had significantly increased risk of oral squamous cell
carcinoma, irrespective of the clinical type of OLP and therapy. there is currently no cure
for OLP. Previous study demonstrated a decreased antioxidant defence and increased oxidative
damage to lipids.DNA and proteins in lichen planus. This oxidative modifications point to
pathophysiological alterations mainly within the basal cell layers of epidermis and at the
dermoepidermal junction. Purslane is an excellent source of vitamin A,C and E and essential
amino acids, has been described as a power food of the future because of its high nutritive
and antioxidant properties. The purpose of the study was to determined the efficacy of
Purslane in the treatment of oral lichen planus.