Overview

Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer

Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
0
Participant gender:
All
Summary
Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Treatments:
Clopidogrel
Esomeprazole
Proton Pump Inhibitors
Ticlopidine
Criteria
Inclusion Criteria:

- We plan to enroll 300 clopidogrel users without baseline gastroduodenal ulcer at
initial endoscopy. The patients will be randomly assigned to receive either (1)
esomeprazole (20 mg qd) plus clopidogrel or (2) clopidogrel treatment alone for 6
months.

Exclusion Criteria:

- 1.serious disease 2.refuse informed consent