Efficacy of Prolonged GnRH Test in Male Adolescents With Postoperative HH
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
The Hypogonadotropic Hypogonadism(HH) could be caused by sellar lesions, sellar surgery or
sellar radiotherapy. The incidence of HH after sellar surgery was higher in men than in
women, and the therapy of HH was insufficient. Gonadotropin-releasing hormone(GnRH)
stimulation test is used to evaluate the function of pituitary-gonadal axis. GnRH can be used
to diagnose and treat fertility disorders and other endocrine disorders caused by HH. After a
single injection of GnRH, the patients with poor response of luteinizing hormone and follicle
stimulating hormone need to take extended provocation test, which is conducive to the
formulation of the following treatment. GnRH pump can pulse subcutaneous injection of
gonadorelin, which can be used as the extended provocation test.