Efficacy of Prabotulinum and Onabotulinum Toxin-A for Facial Wrinkles

• Status: Completed
• Trial end date: 2021-01-15
• Target enrollment: 0
• Participant gender: All

Summary

The appearance of facial wrinkles, lines, or folds is a natural phenomenon during aging. Different scales help classify wrinkles objectively, such as the Facial Wrinkle Scale. Others help classify patients' subjective perspectives, like the Face-Q questionnaire. The application of Botulinum Toxin is the most performed non-surgical aesthetic procedure in the world to treat facial expression lines. The present study aims to compare the efficacy of onabotulinum toxin-A (BOTOX®) and prabotulinum toxin-A (NABOTA®) to treat expression lines in the upper third of the face, based on objective and subjective follow-up, using the FWS scale and FACE-Q questionnaire, respectively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Instituto de Oftalmología Fundación Conde de Valenciana

Criteria

Inclusion Criteria:

• 25 and 40 years of age

• Diagnosis of expression lines in the upper facial third of any degree

• Wished to improve their aesthetic appearance

Exclusion Criteria:

• Known allergy to milk protein or albumin

• Pregnancy and lactation

• Cardiovascular or neuromuscular disease

• Recent history of infections in the facial region

• Concomitant intake of aminoglycosides or cyclosporine A