Efficacy of Polymyxin B Against Infections Caused by Extensively Drug-resistant (XDR) Gram-Negative Bacteria

• Status: Unknown status
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study is to evaluate the efficacy of Polymyxin B for treatment Gram negative bacterial infection. The hypothesis of study is Polymyxin B would be the new antibacterial agents for Thai Gram negative infected patients in case of desirable outcomes and minimal side effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Polymyxin B; Polymyxins

Criteria

Inclusion Criteria:

• Age 18-75 year-old

• The infection caused by carbapenem-resistant (CR) Enterobacteriaceae, CR P.aeruginosa or CR A. baumannii which susceptible to colistin

• The duration of treatment approximately between 7-14 days

• Kidney function, according to Kidney Disease Improving Global Outcomes (KDIGO) classification, should less than stage 4 and no replacement therapy in all modality.

• The patients are anticipated to live more than 48 hrs after participation.

• In case of Colistin administration beforehand, it should not exceed 24 hrs.

• All of participants should be willing to join this project.

Exclusion Criteria:

• Pregnancy and lactation

• End stage renal disease who take renal replacement therapy

• Any type of Neuromuscular disease

• Body mass index exceed 30

• Infection that require treatment more than 14 days