Efficacy of Piroxicam as a Perioperative Analgesic for Patients Undergoing Fixation of Maxillofacial Fractures

• Status: Unknown status
• Trial end date: 2020-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients were allocated randomly by a computer-generated list into two groups: piroxicam group who received induction with piroxicam(0.4mg/kg) IM and GA group where piroxicam was not given. Paracetamol IV (24 mg/kg given slowly over 20 minutes) was received by both groups.

After general anesthesia was induced and venous access established, fentanyl 2 micrograms/kg was given and an appropriate size endotracheal tube was placed intranasal, intubation was facilitated by Atracurium (0.5 mg/kg). All patients were mechanically ventilated with pressure-controlled mode with targeted EtCO 2 (30-35 mmHg)and anaesthesia was maintained by 1 MAC Isoflurane in a mixture of 50% air and oxygen in all cases throughout the procedure and oral pack was introduced.

At the end of the procedure,muscle relaxation was reversed by neostigmine 50 μg/kg and atropine sulfate 15μg/kg then the endotracheal tube was removed and general anesthesia was discontinued. Patients were taken to the post anesthesia care unit (PACU).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Analgesics; Piroxicam

Criteria

Inclusion Criteria:

• patients aged from 16-25 years old

• ASAI II

• scheduled for open reduction and internal fixation of mandibular or maxillary fractures

Exclusion Criteria:

• a history of convulsion,

• gastrodudenal ulcer

• hematological disorders

• patient suffering from hepatic or renal dysfunction

• concomitant use of anticoagulants

• refusal of the patients to participate

• patients younger than 12 years