Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the efficacy and safety of a peri-incisional
multimodal injection for post-operative pain control following operative management of femur
fractures. Enrolled subjects will be prospectively randomized into either the peri-incisional
injection or control cohorts. Patients will be treated with standard of care surgical
techniques by the treating orthopaedic surgeon for the patient's specific fracture pattern.
The patients randomized into the injection cohort will receive an intra-operative injection
with 400 mg ropivacaine, 0.6 mg epinephrine, 5 mg and morphine into the local superficial and
deep peri-incisional tissues while under general anesthesia. Visual analog pain scores will
be collected every 4 hours after surgery for the first two post-operative days. Total
narcotic consumption will also be recorded over eight hour intervals for the first two
post-operative days. Medication related side effects will be monitored. The investigators
hypothesize that the peri-incisional injection cohort will demonstrate an improved pain
profile and utilize less parenteral narcotic analgesia in the early post-operative period.