Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

• Status: Completed
• Trial end date: 2020-10-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the additional effect of paracetamol in combination with morphine for analgesia, respectively to test/confirm an opioid sparing effect due to the additional use of Paracetamol, as well as the reduction of adverse drug reactions of morphine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bruno Minotti
• Treatments: Acetaminophen; Morphine

Criteria

Inclusion Criteria:

• Patient with pain with Pain-score is more or equal than four in a numeric rating scale from zero to ten (i.e. indication for a treatment with morphine)

• Age over 18

• Signed informed consent. In case, patient is not able to sign the informed consent due to pain, at least verbal consent has to be provided. After pain relief, written informed consent with data and time has to be obtained

Exclusion Criteria:

• Analgesia in the past last 6 hours prior to visit at the emergency department

• Current Analgesia with long-acting/extended-release drugs

• Current Analgesia with opioids

• Chronic pain syndrome

• Contraindication for either paracetamol or morphine

• Patient's refusal of paracetamol or morphine treatment

• Pregnancy or Breastfeeding

• GCS < 13

• SpO2 < 90% with a maximum of 4 L/Min O2

• Systolic Blood Pressure < 90 mmHg

• "Fast Track"/Notfallpraxis patients