Efficacy of Palmitoylethanolamide-polydatin Combination on Chronic Pelvic Pain in Patients With Endometriosis
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
One of the main symptoms of endometriosis is pain, but his pathogenesis is not fully
understood. The detection of mast cells in the endometriosis lesions supports the hypothesis
that mast cell degranulation may contribute to development of pain and hyperalgesia.
N-acylethanolamines (NAEs) are a class of endogenous compounds that regulate inflammation and
pain, controlling mast-cell activation. The aim of the study is to investigate the efficacy
of palmitoylethanolamide-polydatin combination on pain relief in symptomatic patients with
endometriosis.