Efficacy of Oral vs. Intravenous Acetaminophen

• Status: Completed
• Trial end date: 2018-01-15
• Target enrollment: 0
• Participant gender: All

Summary

The comparative efficacy of intravenous (IV) to oral (PO-'per os') acetaminophen in the management of postoperative pain is understudied and largely unknown. In this observer blinded randomized clinical trial, investigators aim to determine the comparative efficacy of PO (preoperative) vs. IV (intraoperative) acetaminophen in a sinus surgery population.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Adult patients aged 18 years or older

• Undergoing elective sinus surgery at Zale Lipshy Hospital

Exclusion Criteria:

• Inability of the patient to follow directions or comprehend either English or Spanish language.

• Disorders of the liver which would make acetaminophen contraindicated (such as hepatitis, liver failure, prior liver transplant, etc).

• Patients with chronic pain manifest by a baseline pain score > 4/10

• Chronic opioid use (>2 weeks continuously), or illicit drug abuse

• Body weight < 50 kg.

• Patients with contraindications to any of the study drugs (such as Malignant Hyperthermia susceptible, celecoxib or sulfa allergy, etc.).

• Patients who have taken analgesic medications on the morning of surgery (prior to arrival).

• Allergy to acetaminophen