Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
For the primary goals, we hypothesize that 1) the oral tobacco product will be more
efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2)
among non-abstainers, the oral tobacco product will lead to greater reduction in cigarette
smoking than medicinal nicotine; and 3) a higher rate of oral tobacco compared to medicinal
nicotine use will be observed during and beyond the treatment period.
For the secondary goals, we hypothesize that 1) both products will equally reduce withdrawal
symptoms from cigarette abstinence; and 2) the toxicant exposure and toxicity will be reduced
dramatically when smokers switch from cigarettes to each of these products; however, this
reduction will be greater with the use of medicinal nicotine.
Phase:
Phase 2
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute
Collaborators:
National Cancer Institute (NCI) National Institute on Drug Abuse (NIDA)