Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis

• Status: Active, not recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Various clinical studies have evaluated the role of probiotics in children with atopic dermatitis, with some studies showing improvement in clinical outcome after supplementation of probiotics and others showing no additional benefit. This study is to provide clinical evidence of effect of a mixture of probiotics in Atopic Dermatitis (AD) patients based on improvement in SCORAD (SCORing Atopic Dermatitis) index.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: B.P. Koirala Institute of Health Sciences
• Collaborator: Nepal Health Research Council

Criteria

Inclusion Criteria:

1. Children with a diagnosis of atopic dermatitis that meet Hanifin and Rajka criteria

2. SCORAD ( SCORing Atopic Dermatitis) index 15- 50 at the time of enrollment

Exclusion Criteria:

1. SCORAD (SCORing Atopic Dermatitis) index <15 or >50.

2. Children treated with systemic corticosteroids, methotrexate, or cyclosporine in the previous 3 months and antibiotics in the previous 2 weeks.

3. Immunocompromised children.

4. Concomitant diagnosis of intolerance to gluten and/ or lactose.

5. Pre-existing hypersensitivity to components contained in the probiotics.

6. Children suffering from chronic infectious diseases.

7. A child with other known systemic diseases (heart, liver or kidney diseases).

8. Known case of short gut syndrome.

9. Refusal of children's parents to participate in the study.