Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain
Status:
Completed
Trial end date:
2003-04-01
Target enrollment:
Participant gender:
Summary
Persistent pain occurs in 50-85 percent of patients who experience the amputation of an
extremity. This study will compare the effectiveness of morphine and mexiletine to placebo in
the treatment of postamputation pain.
It is hypothesized that the effects of opioids and mexiletine on behavior and mental
functioning in patients with postamputation pain are unlikely to be significant barriers to
the clinical use of the drugs.
Phase:
Phase 2
Details
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)