Overview

Efficacy of Neural Prolotherapy in Treatment of Meralgia Paresthetica

Status:
Completed
Trial end date:
2019-09-30
Target enrollment:
0
Participant gender:
All
Summary
Meralgia paresthetica is an entrapment neuropathy of the lateral femoral cutaneous nerve. Its main manifestation is neuropathic pain on the lateral aspect of the thigh. Neural prolotherapy has shown improvement and relieve of neuropathic pain. The aim of the current study was to assess the efficacy of neural prolotherapy (subcutaneous perineural injection of dextrose 5% solution) on reliving pain and improvement of function and quality of life in patients with meralgia paresthetica.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Alexandria
Criteria
Inclusion Criteria:

- The patients had clinical evidence of meralgia paresthetica which was based on the
following: (i) the presence of pain, paraesthesia and numbness over the anterior and
lateral aspect of the thigh; (ii) exacerbation of these symptoms on walking, standing
and hip extension; and (iii) meralgia paresthetica was confirmed
electrophysiologically by nerve conduction study with or without somatosensory evoked
potentials.

- The symptoms needed to be present for at least three months.

- The patients should be unresponsive to conservative treatment. The conservative
treatment included lifestyle modification including weight reduction, activity
modification (avoid the use of seat belts) and avoidance of tight underwear (tight
garments such as jeans, uniforms); non-steroidal anti-inflammatory drugs and
anticonvulsants for neuropathic pain; and physiotherapy.

Exclusion Criteria:

- Diabetes mellitus.

- Endocrine disorders.

- Metabolic disorders.

- Systemic rheumatologic disorders.

- Neurological disorders including peripheral neuropathy, lumbar radiculopathy and
lumbar plexopathy.

- Coagulopathy.

- Anticoagulant treatment.

- Current skin or soft tissue infection at or near the site of injection.

- Prior local injection of corticosteroid in the past year for meralgia paresthetica.

- Prior neural prolotherapy in the past year for meralgia paresthetica.

- Prior surgery in the affected thigh region.

- Patients presented with a systemic active inflammatory condition or infection.

- Pregnancy.

- Patients refused to participate in the study