Efficacy of NAC for the Prevention and Relief of PIPN in Women With Ovarian, Tubal, and Peritoneal Cancer
Status:
Not yet recruiting
Trial end date:
2023-12-30
Target enrollment:
Participant gender:
Summary
Ovarian cancer is third most common gynecologic cancer in Thai woman, treatment including
surgery followed by chemotherapy.
Patient usually received paclitaxel every 3 week for 6 cycles, paclitaxel induce peripheral
neuropathy is common dose dependent side effect which can disturb quality of life, result in
chemotherapy dose reduction or discontinuation leading to poor prognosis and decreased
survival Mechanism of PIPN including inflammation, promotion of microtubule polymerization
and inhibition of depolymerization, and oxidative stress N-acetylcysteine is acetylated form
of l-cysteine, might reduce oxidative stress. NAC can restore glutathione level, which is
potent natural antioxidant. NAC might reduce PIPN