Overview

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to compare different medication combinations used in a periarticular injection after total knee replacement surgery(TKR). A periarticular injection is an injection that is given into the tissues surrounding the knee joint. The injection is given while the patient is still in surgery. The study will compare the level of pain management, length of hospital stay, range of motion and side effects from subjects receiving one of four different combinations of medication in a periarticular injection. The medications used in the injections are approved medications routinely used for pain management. Approximately 160 subjects will participate in this study. The surgeon, study personnel, and patients will be blinded to the combination of medications each patient receives. The pharmacist will prepare the 4 different combinations of medications, randomize each patient to the particular combination of medications, and maintain the study drug documentation.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Towson Orthopaedic Associates
Treatments:
Clonidine
Epinephrine
Epinephryl borate
Ketorolac
Ketorolac Tromethamine
Racepinephrine
Ropivacaine
Criteria
Inclusion Criteria:

1. Men and Women aged 30 to 85 years

2. Voluntary, written informed consent given to participate in this clinical
investigation

Exclusion Criteria:

1. Pregnant or lactating women

2. Presence of allergies or contraindication to any medications indicated in the study

3. Contraindication to or failure of spinal anesthesia

4. Known drug or alcohol abuse or psychologic disorder that could affect follow-up care
or treatment outcomes

5. Patients with a diagnosis of inflammatory arthritis

6. Previous major bone surgery in the operative knee

7. Simultaneous, bilateral TKRs