Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures
Status:
Completed
Trial end date:
2018-09-21
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the efficacy and safety of a peri-articular
multimodal injection for post-operative pain control following operative management of
closed, rotational ankle fractures. Enrolled subjects will be randomized to either receive or
not receive intra-operative injections in addition to standard opioid analgesic regimens.
Patients will be treated with standard of care surgical techniques by the treating
orthopaedic surgeon for the patient's specific fracture pattern. The patients randomized into
the injection cohort will receive a 25cc intra-operative injection with 200 mg ropivacaine,
0.6 mg epinephrine, 5 mg and morphine into the local superficial and deep peri-incisional
tissues while under general anesthesia. Total post-operative opioid consumption expressed in
morphine equivalent dose will be recorded, including IV and oral opioids. Time in hours from
operation conclusion to discharge and discharge disposition (to where the patient is
discharged) will also be recorded. Post-operative pain scores will be assessed and recorded
in the immediate post-operative period and every 4 hours subsequently until the patient is
discharged. Medication related side effects will be monitored. The investigators hypothesize
that the injection cohort will have reduced pain scores, lower narcotic requirements, shorter
length of stay, and be more likely to discharge to home following surgery.