Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery
Status:
Unknown status
Trial end date:
2008-06-01
Target enrollment:
Participant gender:
Summary
The patient population requiring hepatic resection can demonstrate an unpredictable risk of
exhibiting peri-operative coagulopathy resulting either from the pre-operative hepatic
pathophysiology or volume of parenchymal resection. Choice of analgesia can be severely
limited.
Currently, the most commonly described use of combined remifentanil infusion and intrathecal
morphine has been in fast-track cardiac surgery. To date, there are no published data
describing its use in the context of major hepatobiliary where the investigators predict it
may provide adequate analgesia with a lower rate of adverse effects over the first 24 hours
after surgery.