Efficacy of Motilitone on Gastric Accommodation in Healthy Adult Patients: Evaluation Using MRI Method
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Functional dyspepsia (FD) is a disorder characterized by chronic or recurrent upper abdominal
pain or discomfort in the absence of a specific structural cause. Improving gastric
accommodation and prokinetic effect seem to be an attractive physiological target in patients
with FD. Motilitone (Dong-A ST, Yongin, Korea) is a new herbal drug that was launched in
December 2011 in Korea for treating patients with FD. The current study aims to evaluate
effects of motilitone on gastric accommodation and emptying after a meal in a group of
healthy volunteers using three-dimensional gastric volume measurements by magnetic resonance
imaging (MRI). Healthy volunteers are randomly allocated to receive either motilitone or
placebo in a double blinded manner. After 5 days of treatment, subjects undergo gastric MRI.
The primary endpoint is gastric accommodation.