Efficacy of Metoclopramide in Poor Ovarian Response IVF Patients
Status:
Not yet recruiting
Trial end date:
2022-07-01
Target enrollment:
Participant gender:
Summary
Poor ovarian response population of ART are considered the biggest challenge for providers.
Hitherto, no one protocol has been proven to be effect in this subgroup of IVF patients.
Metoclopramide belongs to the antiemetic group, used for motion sickness and during early
gestation for hyperemesis gravidarum.
The mechanism of action is antagonisim to dopamine receptors. We hypothesize than by blocking
dopamine receptors and decreasing the dopaminergic tone there is a possibility to increase
the sensitivity of ovarian response to gonadotropins during controlled ovarian stimulation
and result in increased oocyte retrival.