Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses
Status:
Not yet recruiting
Trial end date:
2029-12-01
Target enrollment:
Participant gender:
Summary
The objective of this Phase 2 study is to evaluate the efficacy of methylene blue
photodynamic therapy (MB-PDT) performed at the time of percutaneous abscess drainage for
disinfection of deep tissue abscesses. The study includes three arms: (1) MB-PDT at a fixed
drug/light dose plus standard of care abscess drainage , (2) MB-PDT at a patient-specific
dose determined by pre-treatment optical measurements plus standard of care abscess drainage
, and (3) standard of care abscess drainage. The primary endpoint is reduction in bacterial
burden from pre- to post-intervention, quantified by culture of abscess aspirates.