Efficacy of Low Dose Naltrexone in Psoriasis

• Status: Completed
• Trial end date: 2019-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Objective of the study is to determine the efficacy of low dose naltrexone in the patients of psoriasis, which is a chronic relapsing and remitting disease. A non-randomized clinical trial was carried out in the Department of dermatology in Jinnah Postgraduate Medical Center, Karachi. All patients with mild, moderate and severe psoriasis with age above 13 years without any co-morbid, were prescribed tablet Naltrexone 6 mg daily after assessing PASI, BSA and DLQI scores before starting treatment. Patients were called monthly for follow up to monitor lipid profiles and liver function tests. After 3 months of treatment, PASI, BSA and DLQI scores were assessed again. The results were significant when analysed with paired t test in SPSS 23.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Jinnah Postgraduate Medical Centre
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• minimum age 13 years

• maximum age 60 years

• both males and females affected with mild, moderate and severe psoriasis.

Exclusion Criteria:

• hypertension

• cardiovascular disorders

• pregnancy

• lactation

• renal failure

• liver failure

• hypersensitivity to drug