Objective of the study is to determine the efficacy of low dose naltrexone in the patients of
psoriasis, which is a chronic relapsing and remitting disease. A non-randomized clinical
trial was carried out in the Department of dermatology in Jinnah Postgraduate Medical Center,
Karachi. All patients with mild, moderate and severe psoriasis with age above 13 years
without any co-morbid, were prescribed tablet Naltrexone 6 mg daily after assessing PASI, BSA
and DLQI scores before starting treatment. Patients were called monthly for follow up to
monitor lipid profiles and liver function tests. After 3 months of treatment, PASI, BSA and
DLQI scores were assessed again. The results were significant when analysed with paired t
test in SPSS 23.