Efficacy of Ketamine-Propofol for Short Surgical Procedures

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

OBJECTIVE: To determine the efficacy of ketamine-propofol anesthesia in a mixture 1:2 (1 mg of ketamine per 2 mg of propofol) for short minimally invasive surgical procedures.

METHODS: The investigators performed a prospective study through randomization of 77 patients undergoing short surgical procedures in two study groups: one received a mixture of ketamine-propofol in a 1:1 ratio, and the other received a 1:2 mixture. Data were stored in an Excel spreadsheet and analyzed using the statistical program Epi-Info (TM) 3.5.3. The investigators performed the comparison of qualitative and quantitative variables.

KEY WORDS: ketamine, propofol, anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidad de Cartagena
• Treatments: Ketamine; Propofol

Criteria

Inclusion Criteria:

1. Patient scheduled for minimally invasive procedures less than an hour to complete:

reduction of dislocations and fractures, lavage and debridement of ulcers, drainage of abscesses, removal of osteosynthesis material, hernia umbilical, thoracotomies, circumcision, curettage, suturing tissue soft, burn care, etc.

2. Patients who have not eaten solid food within 8 hours before or liquids in the two hours before

3. Be an adult or emancipated minor

Exclusion Criteria:

1. An acute lung infection

2. Procedures involving stimulation of the posterior pharynx

3. Coronary heart disease, CHD, and angina or suspected aortic dissection

4. History of uncontrolled hypertension or BP > 140/90mmHg

5. Injury cerebral focal neurological deficit or loss of consciousness

6. Mass in CNS, hydrocephalus or other conditions with increased intracranial pressure.

7. Glaucoma or eye damage

8. History of porphyrias

9. Prior hyperthyroidism or thyroid hormone replacement

10. Pregnancy or lactation Major psychiatric disorder

11. Previous mild allergic reaction to ketamine, propofol, lidocaine, or egg albumin

12. Patient who refuses to provide informed consent