Overview

Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus

Status:
Withdrawn
Trial end date:
2021-05-18
Target enrollment:
0
Participant gender:
All
Summary
The study will investigate the efficacy of the N-methyl-D-aspartate receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used for burst suppression that target the gamma-aminobutyric acid adrenergic receptors.
Phase:
Phase 2/Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Alabama at Birmingham
Treatments:
Anticonvulsants
Ketamine
Propofol
Criteria
Inclusion Criteria:

- Patients more than 18 years of age with a diagnosis of status epilepticus

- Considered for burst suppression therapy after failing 2 or 3 anti-epileptic
medications

Exclusion Criteria:

- Post anoxic status epilepticus

- Pregnant women, as confirmed by urine, or blood human chorionic gonadotropin,
ultrasound or physical exam

- Prisoners

- Age less than 18 years

- Allergy or sensitivity to the drug in question