Efficacy of Iontophoresis-assisted AFL-PDT in Actinic Keratosis

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed photodynamic therapy (AFL-PDT).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dong-A University
• Treatments: EMLA; Lidocaine; Lidocaine, Prilocaine Drug Combination; Prilocaine

Criteria

Inclusion Criteria:

• Korean patients aged ≥ 18 years who had biopsy-confirmed AK lesions

Exclusion Criteria:

• lactating or pregnant women

• patients with porphyria or a known allergy to any of the constituents of the MAL cream and lidocaine

• patients with systemic disease, history of malignant melanoma, tendency of melasma development or keloid formation, any AK treatment of the area in the previous 4 weeks, or any conditions associated with a risk of poor protocol compliance; and patients on immunosuppressive treatment

• metal-containing device (cardiac pacemaker, orthopaedic implants, gynaecological devices)

• cardiac arrhythmia

• large skin erosion