Overview

Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD

Status:
Recruiting
Trial end date:
2022-06-30
Target enrollment:
0
Participant gender:
All
Summary
ACTIVE is a phase II B efficacy monocenter, prospective, randomized, controlled double blinded trial, in which intra-discal autologous adult BM-MSC therapy will be compared with sham treated controls. This trial will evaluate the efficacy of intradiscal injection of autologous BM-MSCs in workers affected by chronic low back pain (LBP) unresponsive to conventional therapy. The efficacy will be evaluated 12 months after the treatment in terms of pain relief (VAS, Visual Analog Scale), functionality (ODI, Oswestry Disability Index), quality of life (SF36, Short Form - 36) and work ability index (WAI).
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Campus Bio-Medico University
Collaborators:
Center for Outcomes Research and Clinical Epidemiology, Italy
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Criteria
Inclusion Criteria:

- Workers (it means subject has worked at least 2 months, even if not continuously, in
the last 6 months)

- Age between 18 and 65 years.

- Signed informed consent.

- Symptomatic chronic LBP due to moderate/severe IDD [modified Pfirrmann score 3-5
(Pfirrmann et al., 2001), Griffith score 4-8 (Griffith et al., 2007)] at max. 4 levels
of the lumbar spine unresponsive to conservative treatment, physical and medical for
at least 6 months. Physical treatment includes physiotherapy. Medical treatments
includes AINS, paracetamol, opioids and myorelaxant.

- Annulus fibrosus intact, demonstrated by MRI.

- Pain baseline > 40 mm on VAS (0- 100).

- NSAID washout of at least 2 days before screening.

- Painkillers washout of at least 24 hours before screening.

- For females of childbearing potential, a negative pregnancy test must be documented at
Screening.

- Men and women should use effective contraception during treatment and for at least 12
months after BM-MSC discontinuation. The complete list of contraceptive methods is
described in the patient information sheet and in the paragraph 6.5. As a
precautionary measure, breast-feeding should be discontinued during treatment with
BM-MSC and should not be restarted after discontinuation of BM-MSC.

Exclusion Criteria:

- Non-workers (it means that the person has worked less than 2 months, although not
continuously, in the last 6 months)

- Congenital or acquired diseases leading to spine deformations that may upset cell
application (scoliosis, isthmus lesion, sacralization and hemisacralization,
degenerative spondilolisthesis).

- Spinal segmental instability assessed by dynamic X-Ray.

- Symptomatic facet joints syndrome on MRI (facet joints hyperintensity and hypertrophy
evaluated at coronal T2 weighted MRI).

- Prior to the screening visit, has received:

- Oral corticosteroid therapy within the previous 3 months, OR

- Intramuscular, intravenous or epidural corticosteroid therapy within the previous
3 months

- Presence of a 5th level with symptomatic IDD (modified Pfirrmann score 3-5, Griffith
score 4-8) in the lumbar spine.

- Spinal canal stenosis (Schizas score > B).

- History of spinal infection.

- Lumbar disc herniation and sciatica.

- Endplate abnormality such as Schmorl's Nodes.

- Previous discal puncture or previous spine surgery.

- IDD with Modic III changes on MRI images.

- Patients not eligible to the intravertebral disc surgery.

- Patients who have the risk to undergo a surgery in the next 6 months.

- Patients with local infusion device/devices for corticosteroids.

- Obesity with body mass index (BMI in Kg/size in m2) greater than 35 (obesity grade
II).

- Participation in another clinical trial or treatment with another investigational
product within 30 days prior to inclusion in the study.

- Abnormal blood tests: hepatic (alanine aminotransferase [ALT] and/or aspartate
aminotransferase [AST] >1.5 × upper limit of normal [ULN]), renal, pancreatic or
biliary disease, blood coagulation disorders, anemia or platelet count of <100 ×
109/L.

- Pregnant or lactating women, or premenopausal women not using an acceptable form of
birth control, are ineligible for inclusion. Contraception will be maintained during
treatment and until the end of relevant systemic exposure. Additional pregnancy
testing will be performed at the end of relevant systemic exposure. The patients will
be required to use contraception from initial treatment administration until 24 months
after the last dose of study drug.

- In each case of delayed menstrual period (over 1 month between menstruations),
confirmation of absence of pregnancy is strongly recommended. The complete list of
contraceptive methods is described in the patient information sheet.

- Positive serology for following infection: Syphilis, HIV, Hepatitis B, or C.

- Contraindication to MRI assessed by the investigator.

- Intolerance or allergy to local anaesthesia.

- Any history of Cancer or immunodeficiency disease.

- Previous transplantation.