Overview
Efficacy of Inhaling Bronchodilator Medications in Chronic Obstructive Pulmonary Disease
Status:
Completed
Completed
Trial end date:
2012-10-01
2012-10-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
Some patients with Chronic Obstructive Pulmonary Disease (COPD) report that they are uncertain whether they achieve clinical benefit using a dry-powder inhaler (DPI). One possible explanation is that the patient is unable to inhale the dry powder bronchodilator medication into the lower respiratory tract due to a low peak inspiratory flow rate (PIFR). A PIFR < 60 l/min is considered to be suboptimal flow for a DPI, including the Diskus device. The hypothesis of the study is that the forced expiratory volume in 1 second (FEV1) measured at two hours after inhalation of the study medication will be higher with arformoterol solution (15 mcg) from a nebulizer compared with salmeterol dry powder (50 mcg) inhaled from the Diskus.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Dartmouth-Hitchcock Medical CenterCollaborator:
SunovionTreatments:
Bronchodilator Agents
Formoterol Fumarate
Salmeterol Xinafoate
Criteria
Inclusion Criteria:- male or female patient 60 years of age or older; diagnosis of COPD; current or former
smoker; previous or current use of Diskus device; PIFR < 60 l/min using the In-check
DIAL against the resistance of the Diskus device; clinically stable.
Exclusion Criteria:
- any patient who has a concomitant disease that might interfere with study procedures
or evaluation; inability to withhold short-acting and long-acting bronchodilators on
the days of testing