Efficacy of Humira in Behcet Patients With Arthritis
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Hypothesis - Behcet's disease is a multisystemic chronic relapsing inflammatory disease,
classified among the vasculitides. The clinical manifestations include mucocutaneous lesions,
articular, ocular, vascular, gastrointestinal and/or central nervous system involvement.
The aetiology of Behcet's disease is unknown, however. Experimental evidence suggests that
TNF-α may play an important role in the pathogenesis of the disease.
To date, case reports and small open-short term studies report the efficacy of anti-TNFα
therapy (Infliximab and Etanercept), especially regarding ocular and mucocutaneous
involvement in Behcet.
There are no double blind long term studies on larger number of patients regarding the
efficacy of anti-TNFα, especially Humira in healing arthritis +/- other manifestations of the
disease.