Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
Up to now, to our knowledge, there is few randomized, large scale study prospectively and
simultaneously comparing the efficacy, adverse effects and patient adherence of these current
recommended 1st-line or 2nd-line regimens for H. pylori eradication in and out of our
country.
The aims of this study are:
1. to compare the efficacy of high dose dual therapy, sequential therapy and
clarithromycin-based triple therapy as 1st-line regimen in H. pylori eradication;
2. to compare the efficacy of high dose dual therapy, sequential therapy and
levofloxacin-based triple therapy as rescue regimen in H. pylori eradication;
3. to compare the patient adherence and adverse effects of these treatment regimens;
4. to investigate factors that may influence H. pylori eradication by these treatment
regimens;
5. to investigate and analyze the prevalence and trend of antibiotic resistance.