Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus

• Status: Unknown status
• Trial end date: 2019-01-30
• Target enrollment: 0
• Participant gender: All

Summary

Is topical application of green tea polyphenols buccal tablet more effective in treatment of patients with symptomatic oral lichen planus in comparison with topical application of corticosteroids and what is the most effective concentration of polyphenols

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University

Criteria

Inclusion Criteria:

• Symptomatic lesions.

• OLP lesions with the diagnosis confirmed both clinically and histopathologically.

• Clinical score higher than 3.

• Disease duration of more than 2 months.

• Absence of dysplasia in histological section

Exclusion Criteria:

• Presence of any visible oral lesion other than OLP.

• Pregnant or breast-feeding women,

• Immuno-deficiency diseases.

• Current malignancy or malignancy in history.

• Concomitant treatment potentially effective on OLP within the previous 2 months such as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs.

• Severe or recurrent infections.

• Lichenoid reaction.

• Patients presents with skin lesions which may require systemic corticosteroid therapy.