Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy

• Status: Unknown status
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The hypothesis of this study is that Gabapentin or Amitriptyline has no role in preemptive analgesia to reduce postoperative pain after lumbar diskectomies.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tabriz University
• Treatments: Amitriptyline; Amitriptyline, perphenazine drug combination; Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• Signed Informed Consent

• Age:18 to 60

• Weight: 60 to 80 Kg

• ASA Class: I,II

• Concordant physical and imaging findings in favor of symptomatic lumbar disk herniation

• Single level lumbar disk herniation unresponsive to medical treatment

Exclusion Criteria:

• Previous consumption of Gabapentin or Amitriptyline

• Known allergy to investigated drugs

• Reluctant to sign informed consent

• Previous history of intolerance to narcotics

• Simultaneous lumbar diskectomy and a fusion technique

• Known renal failure

• Pregnancy

• Contraindications to Amitriptyline or Gabapentin prescription

• Unable to use PCA

• Habitual use of alcohol or opium

• History of analgesic consumption during the last 24hours