Efficacy of Fish Oil or Olive Oil Supplementation on the Health Effects of Ozone Exposure in Healthy Young Subjects
Status:
Completed
Trial end date:
2020-12-18
Target enrollment:
Participant gender:
Summary
Purpose: A growing body of epidemiological data suggests an increased risk of cardiovascular
events associated with air pollution. One of the common air pollutants, ozone, has been shown
to induce oxidative stress and inflammation in the cardiovascular and respiratory systems.
This proposed study is to examine the efficacy of fish oil and olive oil in modulating
cardiovascular and pulmonary functions after ozone exposure. The objective is to understand
the mechanistic basis for the health effects of ozone relative to those air pollutants.
Treatment groups will include forty healthy young adults who will be given dietary
supplementation of fish oil or olive oil. A control group will consist of 20 healthy
volunteers who will receive no supplements. After 4 weeks, subjects will be exposed to clean
air for 2 hours on the first day, then ozone for 2 hours on the second day. Cardiac rhythm,
pulmonary function, vascular responses, endothelial function, and markers of coagulation and
airway inflammation pre- and post- ozone exposure will be measured. This study is designed to
build on the previous nutritional supplement interventional studies (UNC IRB # 07-0190 and
UNC IRB # 11-1807), in order to understand the mechanism of action of particulate pollutants
in comparison to that of ozone, a known oxidant air contaminant.
Participants: A total of sixty healthy 18-35 year-old male and female subjects will be
involved in the study.
Procedures (methods): Forty healthy young adults will receive dietary supplementation
consisting of fish oil or olive oil for 4 weeks. The control group includes 20 healthy
volunteers who will receive no supplements in the study. After 4 weeks of supplementation or
control regiment, each subject will be exposed to clean air for 2 hours on the first day,
then ozone for 2 hours on the second day.