Efficacy of Extended Release Tramadol for Treating Prescription Opioid Withdrawal

• Status: Completed
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Prescription opioid addiction is a growing public health problem and more pharmacologic treatments are needed because current approved medications have had limited patient acceptance (naltrexone), limited availability (methadone), and concerns about misuse and diversion (methadone and buprenorphine). Tramadol is a currently approved medication used to treat moderate-severe pain, and initial studies demonstrate that it may be useful for treatment of the uncomfortable syndrome of opioid withdrawal without producing euphoric effects. This study will determine whether two different doses of extended release tramadol can treat opioid withdrawal and whether tramadol itself produces withdrawal after it is no longer taken.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Michelle Lofwall; University of Kentucky
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Tramadol

Criteria

Inclusion Criteria:

• Addicted to opioids

Exclusion Criteria:

• Any major medical or psychiatric disorder that would be contraindicated for participation