Efficacy of Everolimus Alone or in Combination With Pasireotide LAR in Advanced PNET
Status:
Terminated
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
This study will estimate the treatment effect of everolimus in combination with pasireotide
LAR relative to everolimus alone on progression-free survival (PFS) in patients with advanced
progressive PNET.
A planned primary analysis was completed with data cut of 02-Apr-2014. The study did not meet
its primary objective, which was based on progression-free survival (PFS) as per local
radiology assessment and was prematurely terminated with the last patient last visit on
19-Feb-2015. However, it is important to note that the data did not reveal any new safety
concerns. It was decided to stop the study and this decision was shared with the study sites
on 31-Jul-2014.