Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study

• Status: Completed
• Trial end date: 2023-04-10
• Target enrollment: 0
• Participant gender: All

Summary

sixty patients, of both sexes, of ASA I or II planned for ambulatory laparoscopic cholecystectomy under general anaesthesia were engaged into 2 groups. Esmolol group were given 1 mg/kg loading dose followed by 30 μg/kg/min throughout the surgery, whereas magnesium sulphate (MgSo4) group were given loading dose 40 mg/kg over 15 mins then maintenance dose 15 mg/kg/h till end of surgery. General anaesthesia was standardized and postoperative analgesia included fentanyl. Variables denoting immediate recovery from anaesthesia, pain score and time of stay in PACU were recorded. White-Song score ≥ 12 along with pain score < 4 were the cut off levels for patients' discharge from PACU.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alexandria University
• Treatments: Esmolol; Magnesium Sulfate

Criteria

Inclusion Criteria:

• patients aged 20-65 years of both sexes

Exclusion Criteria:

• patients on chronic use or known allergic to the study drugs

• body mass index >35 kg/m2,

• significant organ dysfunction, cardiac dysrhythmias, neuromuscular diseases

• liver or renal disease,

• known asthma or reactive airway diseases.