Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Cancer pain is one of the most common and problematic symptoms. Opioids are typically the
most common drugs used in the treatment of cancer pain,they are limited due to their side
effects.
Tramadol is a centrally acting non-opiate analgesic with low affinity for μ-opioid receptors,
and is effective in the treatment of moderate to severe pain.
Neuropathic pain is typically not amenable to standard opiate therapy, and the addition of
tricyclic antidepressants or/and antiepileptic drugs can offer a very effective treatment
strategy in such patients.
Duloxetine is a Serotonin Norepinephrine Reuptake Inhibitor (SNRI) that has been used
traditionally for its antidepressant qualities and has also analgesic benefit in the
treatment of neuropathic pain. Duloxetine exerts its analgesic action through central and
peripheral pain modulation .