Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients With Severe Preeclampsia

• Status: Completed
• Trial end date: 2009-05-30
• Target enrollment: 0
• Participant gender: Female

Summary

Both preeclampsia and eclampsia are important health problems, being an important cause of maternal death in the world.

Nifedipine has been used as the drug of choice for the treatment of hypertension during puerperium for more than 25 years.

Diltiazem is an alternative calcium antagonist that is 1000 times less potent than nifedipine.

There are no reports in the literature, no randomized clinical trials that prove the effectiveness of diltiazem for the control of blood pressure in post-partum patients with severe preeclampsia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital de la Mujer
• Collaborators: Calzada-Mendoza, Claudia, PhD; Ocharan-Hernández, Esther, MD, PhD; Vargas-De-León, Cruz, MSc
• Treatments: Diltiazem

Criteria

Inclusion Criteria:

The following parameters of all patients were within the normal range: hematic biometry, urine and glucose tests, aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine, blood coagulation test including prothrombin time and activated partial thromboplastin time. Electrocardiogram and chest radiography showed no pathological data.

Exclusion Criteria:

When the patient falls outside of the aforementioned parameters, or subjects with unstable medical conditions.