Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty

• Status: Recruiting
• Trial end date: 2024-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of 75 mg of Pregabalin and 150 mg of Pregabalin in postoperative pain control after TKA.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thammasat University
• Treatments: Pregabalin

Criteria

Inclusion Criteria:

1. Symptomatic primary knee osteoarthritis undergoing unilateral TKA

2. Aged between 55 and 80 years old

3. Comply with protocol

Exclusion Criteria:

1. Allergy to any of the medications in this protocol (Pregabalin, Morphine, Paracetamol, Celecoxib, Tramadol, Aspirin)

2. Secondary osteoarthritis of the knee including autoimmune diseases and post-traumatic

3. Previous surgery on the knee

4. Contraindicated to spinal anesthesia (SB) or Adductor canal block (ACB)

5. GFR < 30ml/min, Severe Liver Function (Child-Pugh C)

6. History of seizure or cerebrovascular diseases